Manchester United XI vs Brighton: Starting lineup, confirmed team news, injury latest for Premier League today

Yoro in for Maguire and Sesko replaces Mount as Fernandes reaches 300 appearances

Bruno Fernandes will make his 300th appearance for Manchester United in the Red Devils’ Premier League clash with Brighton this evening.

Harry Maguire , who was the hero as he notched a late winner against Liverpool a week ago, misses out altogether with a knock while Mason Mount - who had also been carrying a knock this week, according to Ruben Amorim - must settle for a place on the bench as Benjamin Sesko is recalled up front.

This weekend’s game comes too soon for Lisandro Martinez , though the Argentine is understood to be progressing well in training as he seeks to return from a long-term knee injury.

Maguire’s absence means Leny Yoro slots into United’s back three against Brighton alongside Matthijs de Ligt and Luke Shaw, while Sesko’s return as the focal point of United’s attack means Matheus Cunha is back to being a left-sided No10, opposite Bryan Mbeumo.

Harry Maguire has been ruled out of today’s match through injury

Manchester United via Getty Imag

United’s skipper, Fernandes, continues in his deeper midfield role alongside Casemiro . That means Manuel Ugarte and Kobbie Mainoo remain substitutes, with Diogo Dalot and Amad Diallo the wing-backs again.

Deadline Day signing Senne Lammens has impressed in his first two outings since replacing Altay Bayindir as United’s first-choice goalkeeper and starts again at Old Trafford, where he was flatteringly compared to the great Peter Schmeichel on debut against Sunderland.

Man Utd XI: Lammens; Yoro, De Ligt, Shaw; Amad, Fernandes, Casemiro , Dalot; Mbeumo, Cunha; Sesko

Subs: Bayindir, Dorgu, Heaven, Malacia, Mazraoui, Mainoo, Mount, Ugarte, Zirkzee

Brighton XI: Verbruggen, Wieffer, Dunk, Van Hecke, Kadioglu, Baleba, Ayari, Minteh, Rutter, De Cuyper, Welbeck

Subs: Steele, Tzimas, Watson, Kostoulas, Milner, Boscagli, Gomez, Coppola, Oriola

Time and date: 5.30pm BST today, Saturday October 25, 2025

Venue: Old Trafford, Manchester

How to watch: Sky Sports